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研究所

Cancer Prevention Center

Members

Department Head -
Senior Scientist Yohko Nakamura

Projects

Japan Multi-institutional Collaborative Cohort Study

A project (Japan Multi-institutional Collaborative Cohort Study) to follow up people's health condition for 20 years and investigate what kind of people could have what kind of diseases under what kind of environments has started in 2005. Laboratory of Cancer Prevention and Epidemiology has started and continued the investigation in Chiba Prefecture since 2006. Firstly, we have focused on around 8100 persons, collected their blood samples, and investigated their health conditions based on their agreement (first investigation). During these investigations, we have conducted the second investigation. Through follow-up study of every year, we seek to develop the individualized preventive method based on constitution diagnosis and molecular marker for cancer risk. Additionally, we have collaborated with other laboratories and extensively promoted genome cohort study that could become the basis of a study contributing to improvement of health condition of the citizens of Chiba Prefecture. During the course of this study, we have identified cancer-related genes and are analyzing their functional significance.

Study of cancer survival rate

Through a research group, we are compiling cancer survival rate (5-year survival rate and 10-year survival rate) from data provided by “Japanese Association of Clinical Cancer Center” organized by the specified facilities of cancer treatment in whole country. Based on data obtained from survey conducted by the 32 specialized facilities participated in Japanese Association of Clinical Cancer Center, the aggregation system of cancer survival rate (KapWeb) is opened to the public on line. In addition to the above-mentioned 5-year survival rate, we have also opened a relative 10-year survival rate that enables users compile much longer survival rate, and our improved system is utilized by a lot of citizens including cancer patients. Notably, our system let breast and non-digestive cancer patients with a prolonged course realize an importance of follow-up together with recurrence. Together, we have updated data and constructed much better system. Through our system, users are able to calculate conditional survival rate (survival rate of patients who survive for a fixed period after diagnosis).

KapWebのHP紹介

Cancer Registry

Department of Health and Welfare of Chiba Prefectural Government has enforced cancer registry project since 1975. According to personal information protection law for cancer registry, our laboratory, as a center for cancer registry of Chiba prefecture, is working on the registration of around 70,000 per year of cancer-related information. Through the report of Chiba Cancer Registry Project, the compiled cancer statistics is opened to the citizens of Chiba prefecture. This cancer statistics contributes to basic pan to promote cancer control programs in Chiba prefecture. Since Jan. 2016, population-based cancer registry project has begun. Due to this project, cancer registry has been promoted at national level and accuracy of data has been improved. While, the international standard of DCO (Death Certificate Only) % that indicates the accuracy of cancer registry is lower than 10%, whereas DCO% of Chiba prefecture cancer registry estimated from the confirmed data of 2018 is 1.7%, which is clearly higher accuracy than the international standard. We are making an effort to further improve the accuracy of data, and also transmit the related information to the public.

千葉県がん登録年次別登録状況

Recent Publications

  1. Naoyuki Okamoto, Haruo Mikami, Yohko Nakamura, Miho Kusakabe, Naohito Yamamoto, Nobuhiro Takiguchi, Yoshihiro Nabeya, Hiroaki Soda, Satoshi Fukasawa Takeshi Kishida, Manabu Shiozawa, Akira Yoshida, Takuya Shimizu, Shunsuke Fujimoto, Mitsuhiro Ueda, Seiichi Inagaki Yohei Miyagi, Hiroki Nagase,  A Nobel Multivariate Index for Cancer Risk Detection Based On the Serum Trace Elements: Metallo-Balance Method. Journal of Cancer Epidemiology and Prevention. 5(1): 2020.
  2. Mikami H, Kimura O, Yamamoto H, Kikuchi S, Nakamura Y, Ando T, Yamakado M. A multicentre clinical validation of AminoIndex Cancer Screening (AICS). Sci. Rep. 9(1):13831. 2019.
  3. Nakatochi M, Nakamura Y, Mikami H, Matsuo H, et al., Genome-wide meta-analysis identifies multiple novel loci associated with serum uric acid levels in Japanese individuals. Commun Biol. 8;2:115. 2019.
  4. Nishiyama T, Nakamura Y, Mikami H, Suzuki S, et al., Genome-wide association meta-analysis and Mendelian randomization analysis confirm ALDH2 influencing on sleep duration in the Japanese population. Sleep. 42(6). pii: zsz046 2019.
  5. Shimanoe C, Mikami H, Nakamura Y, Wakai K, et al., A genome-wide association study of coping behaviors suggests FBXO45 is associated with emotional expression. Genes Brain Behav. 18(2):e12481 2019.
  6. Ando K, Nakamura Y, Nagase H, Nakagawara A, Koshinaga T, Wada S, Makishima M. Co-Inhibition of the DNA Damage Response and CHK1 Enhances Apoptosis of Neuroblastoma Cells. Int J Mol Sci. 20(15). 2019.
  7. Islam MS, Takano R, Yokochi T, Akter J, Nakamura Y, Nakagawara A, Tatsumi Y. Programmed expression of pro-apoptotic BMCC1 during apoptosis, triggered by DNA damage in neuroblastoma cells. BMC Cancer. 19(1):542. 2019.
  8. Shakhova I, Nakamura Y, Nakagawara A, et al., PPP3CB contributes to poor prognosis through activating nuclear factor of activated T-cells signaling in neuroblastoma. Mol Carcinog. 58(3):426-435. 2018.
  9. Nakamura Y, Nakagawara A, et al., Identification of novel candidate compounds targeting TrkB to induce apoptosis in neuroblastoma. Cancer Med. 3:25-35, 2014.

Departments and Projects